What you will learn:
- Novel sample preparation of whole blood from Mitra
- Mass Spectrometry of whole blood
- Biomarker discovery using at-home sampled blood
Biomarkers of colorectal polyps from at-home collected dried blood spots
Pre-cancer, colorectal polyp, biomarker discovery using novel sample preparation and MS from at-home collected blood in Mitra.
Sangui Bio is conducting a colorectal polyp study to identify biomarkers that predict large pre-cancerous polyps. 1400 at-home blood samples have been collected using Mitra. The highest risk group in terms of progression to cancer is those with polyps 10 mm or larger. The control group is defined as polyps 5 mm or smaller, including cases with no detected polyps. The blood samples were analyzed using novel sample preparation and MS. Over 2500 proteins were identified and quantified from each sample and several hundred proteins are significantly different.
Of particular interest for proteomics scientists, biomarker scientists, and all interested in patient centric microsampling.
Speaker:
Ben Herbert
Chief Scientific Officer, Sangui Bio, Australia
Ben Herbert has 40 years of experience in protein chemistry, sample preparation, fractionation, and proteomics. He has gained international recognition as one of key innovators in sample preparation, fractionation and the use of proteomics. His research papers and chapters have been cited 7400 times and his H-index measurement of research impact is 41. Ben has supervised 9 PhD students to completion and currently co-supervises 1 PhD student.
Moderated by:
Neil Spooner
Chair and Co-founder, Patient Centric Sampling Interest Group
Neil is the Co-founder and Chair of the PCSIG. He is also the Founder of Spooner Bioanalytical Solutions, helping companies to integrate biological fluid microsampling, and patient centric sampling and analysis into workflows. He also works with organizations to develop technologies and introduce them to the market. Neil also assists organizations with their understanding of emerging trends in the pharmaceutical industry and bioanalysis. Neil is a Senior Visiting Research Fellow at the University of Hertfordshire, Editor in Chief of the journal, Bioanalysis and Chair of the Reid International Bioanalytical Forum. He has published over 70 peer reviewed manuscripts and delivered over 50 podium presentations.
Ben Herbert
Chief Scientific Officer, Sangui Bio, Australia
Ben Herbert has 40 years of experience in protein chemistry, sample preparation, fractionation, and proteomics. He has gained international recognition as one of key innovators in sample preparation, fractionation and the use of proteomics. His research papers and chapters have been cited 7400 times and his H-index measurement of research impact is 41. Ben has supervised 9 PhD students to completion and currently co-supervises 1 PhD student.
Moderated by:
Neil Spooner
Chair and Co-founder, Patient Centric Sampling Interest Group
Neil is the Co-founder and Chair of the PCSIG. He is also the Founder of Spooner Bioanalytical Solutions, helping companies to integrate biological fluid microsampling, and patient centric sampling and analysis into workflows. He also works with organizations to develop technologies and introduce them to the market. Neil also assists organizations with their understanding of emerging trends in the pharmaceutical industry and bioanalysis. Neil is a Senior Visiting Research Fellow at the University of Hertfordshire, Editor in Chief of the journal, Bioanalysis and Chair of the Reid International Bioanalytical Forum. He has published over 70 peer reviewed manuscripts and delivered over 50 podium presentations.
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